Non-viable Borrelia burgdorferi induce inflammatory mediators and apoptosis in human oligodendrocytes

@article{Parthasarathy2013NonviableBB,
  title={Non-viable Borrelia burgdorferi induce inflammatory mediators and apoptosis in human oligodendrocytes},
  author={Geetha Parthasarathy and Helene B. Fevrier and Mario T. Philipp},
  journal={Neuroscience Letters},
  year={2013},
  volume={556},
  pages={200-203}
}
In previous studies, exposure to live Borrelia burgdorferi was shown to induce inflammation and apoptosis of human oligodendrocytes. In this study we assessed the ability of non-viable bacteria (heat killed or sonicated) to induce inflammatory mediators and cell death. Both heat-killed and sonicated bacteria induced release of CCL2, IL-6, and CXCL8 from oligodendrocytes in a dose dependent manner. In addition, non-viable B. burgdorferi also induced cell death as evaluated by terminal… Expand
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