Non-ulcerative cutaneous lesion in immunodeficient mice with Leishmania amazonensis infection.

@article{Terabe1999NonulcerativeCL,
  title={Non-ulcerative cutaneous lesion in immunodeficient mice with Leishmania amazonensis infection.},
  author={Masaki Terabe and Takashi Kuramochi and Toshimitsu Hatabu and Mamoru Ito and Y. Ueyama and Ken Katakura and Shin-ichiro Kawazu and Takashi Onodera and Yoshitsugu Matsumoto},
  journal={Parasitology international},
  year={1999},
  volume={48 1},
  pages={47-53}
}
Cutaneous leishmaniasis begins as papules or nodules at the site of promastigote inoculation. The next key pathogenic event in this disease is the formation of an ulcer at this site. Leishmania infection in immunodeficient mice, however, showed non-ulcerative cutaneous lesions suggesting the involvement of the immune system in ulcer formation. Severe combined immunodeficient (SCID), recombination-activating gene 2 knockout (RAG-2-/-), and immunocompetent mice were inoculated subcutaneously with… CONTINUE READING