Non-typeable Haemophilus influenzae chronic colonization in chronic obstructive pulmonary disease (COPD)

@article{Short2021NontypeableHI,
  title={Non-typeable Haemophilus influenzae chronic colonization in chronic obstructive pulmonary disease (COPD)},
  author={Bryn Short and Stephen A Carson and Anna-Claire Devlin and James A Reihill and Anne Crilly and William Gordon Mackay and Gordon Ramage and Craig Williams and Fionnuala T. Lundy and Lorcan P Mcgarvey and Keith D. Thornbury and S Lorraine Martin},
  journal={Critical Reviews in Microbiology},
  year={2021},
  volume={47},
  pages={192 - 205}
}
Abstract Haemophilus influenzae is the most common cause of bacterial infection in the lungs of chronic obstructive pulmonary disease (COPD) patients and contributes to episodes of acute exacerbation which are associated with increased hospitalization and mortality. Due to the ability of H. influenzae to adhere to host epithelial cells, initial colonization of the lower airways can progress to a persistent infection and biofilm formation. This is characterized by changes in bacterial behaviour… Expand
1 Citations
The Role of Non-Typeable Haemophilus influenzae Biofilms in Chronic Obstructive Pulmonary Disease
TLDR
The evidence for the existence of NTHi biofilms and their impact in the COPD lung is explored and the nature of chronic and recurrent NTHI infections in acute exacerbations of COPD could have important implications for clinical treatment and identification of novel bactericidal targets. Expand

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