Non-typeable Haemophilus influenzae chronic colonization in chronic obstructive pulmonary disease (COPD)

  title={Non-typeable Haemophilus influenzae chronic colonization in chronic obstructive pulmonary disease (COPD)},
  author={Bryn Short and Stephen A Carson and Anna-Claire Devlin and James A Reihill and Anne Crilly and William Gordon Mackay and Gordon Ramage and Craig Williams and Fionnuala T. Lundy and Lorcan P Mcgarvey and Keith D. Thornbury and S Lorraine Martin},
  journal={Critical Reviews in Microbiology},
  pages={192 - 205}
Abstract Haemophilus influenzae is the most common cause of bacterial infection in the lungs of chronic obstructive pulmonary disease (COPD) patients and contributes to episodes of acute exacerbation which are associated with increased hospitalization and mortality. Due to the ability of H. influenzae to adhere to host epithelial cells, initial colonization of the lower airways can progress to a persistent infection and biofilm formation. This is characterized by changes in bacterial behaviour… Expand
1 Citations
The Role of Non-Typeable Haemophilus influenzae Biofilms in Chronic Obstructive Pulmonary Disease
The evidence for the existence of NTHi biofilms and their impact in the COPD lung is explored and the nature of chronic and recurrent NTHI infections in acute exacerbations of COPD could have important implications for clinical treatment and identification of novel bactericidal targets. Expand


Lower airway colonization and inflammatory response in COPD: a focus on Haemophilus influenzae
This review discusses host immunity that offers protection against H. influenzae and how disturbance of these mechanisms, combined with pathogen mechanisms of immune evasion, promote persistence of H. Influenzae in the lower airways in COPD. Expand
Haemophilus influenzae and the lung (Haemophilus and the lung)
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  • Medicine
  • Clinical and Translational Medicine
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Treatment of respiratory tract infection with Haemophilus influenzae is often only partially successful with ongoing infection and inflammation. Expand
The adhesins of non-typeable Haemophilus influenzae
NTHi infection in the lungs is responsible for the onset of acute exacerbations in chronic obstructive pulmonary disease (COPD) and further research into these immunogenic proteins would further understand and enable a basis for better combatting NTHi disease. Expand
Nontypeable Haemophilus influenzae: understanding virulence and commensal behavior.
Biofilm formation explains many of the observations seen in chronic otitis media and chronic bronchitis, however, NTHi biofilms seem to lack a biofilm-specific polysaccharide in the extracellular matrix, a source of controversy regarding their relevance. Expand
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It is proposed that recruitment of neutrophils facilitates NTHi biofilm formation on mucosal sites by the initiation of neut Phosphorylcholine and neutrophil extracellular traps. Expand
Non-typeable Haemophilus influenzae, an under-recognised pathogen.
Standardised surveillance protocols and typing methodologies to monitor this emerging pathogen should be implemented and international scientific organisations need to raise the profile of NTHi and to document the pathobiology of this microbe. Expand
Discovery and Contribution of Nontypeable Haemophilus influenzae NTHI1441 to Human Respiratory Epithelial Cell Invasion
NTHI1441 is revealed as a novel NTHi virulence factor expressed during infection of the COPD lower airways that contributes to invasion of host respiratory epithelial cells. Expand
Infection as a comorbidity of COPD
  • S. Sethi
  • Medicine
  • European Respiratory Journal
  • 2010
Enhanced understanding of the host–pathogen interaction is needed to better prevent and treat respiratory tract infection in COPD. Expand
Strain-specific immune response to Haemophilus influenzae in chronic obstructive pulmonary disease.
Development of an immune response to H. influenzae supports its role in causing exacerbations, and the strain specificity of the immune response likely represents a mechanism of recurrent exacerbations. Expand
Pathogenesis of Bacterial Exacerbations of COPD
Improved understanding of the host-pathogen interaction in the airways in COPD will lead to novel approaches to prevention and treatment of exacerbations. Expand