Non-transferrin bound iron in Thalassemia: differential detection of redox active forms in children and older patients.

@article{Breuer2012NontransferrinBI,
  title={Non-transferrin bound iron in Thalassemia: differential detection of redox active forms in children and older patients.},
  author={William J. Breuer and Hussam Ghoti and Ahmmad Shattat and Ada Goldfarb and Ariel Koren and Carina Levin and Eliezer A. Rachmilewitz and Zvi Ioav Cabantchik},
  journal={American journal of hematology},
  year={2012},
  volume={87 1},
  pages={
          55-61
        }
}
Non-transferrin bound iron (NTBI) is commonly detected in patients with systemic iron overload whose serum iron-binding capacity has been surpassed. It has been perceived as an indicator of iron overload, impending organ damage and a chelation target in poly-transfused thalassemia patients. However, NTBI is a heterogeneous entity comprising various iron complexes, including a significant redox-active and readily chelatable fraction, which we have designated as "labile plasma iron" (LPI). We… CONTINUE READING
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