Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation.

@article{Juliana2012NontranscriptionalPA,
  title={Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation.},
  author={Christine A Juliana and Teresa Fernandes-Alnemri and Seokwon Kang and Andrew Farias and Fengsong Qin and Emad S. Alnemri},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 43},
  pages={36617-22}
}
The NLRP3 inflammasome is a key component of the innate immune response to pathogenic infection and tissue damage. It is also involved in the pathogenesis of a number of human diseases, including gouty arthritis, silicosis, atherosclerosis, and type 2 diabetes. The assembly of the NLRP3 inflammasome requires a priming signal derived from pattern recognition or cytokine receptors, followed by a second signal derived from extracellular ATP, pore-forming toxins, or crystalline materials. How these… CONTINUE READING
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