Non-transcriptional control of DNA replication by c-Myc

@article{Dominguezsola2007NontranscriptionalCO,
  title={Non-transcriptional control of DNA replication by c-Myc},
  author={D. Dominguez-sola and C. Ying and C. Grandori and L. Ruggiero and B. Chen and M. Li and D. Galloway and W. Gu and J. Gautier and R. Dalla‐Favera},
  journal={Nature},
  year={2007},
  volume={448},
  pages={445-451}
}
The c-Myc proto-oncogene encodes a transcription factor that is essential for cell growth and proliferation and is broadly implicated in tumorigenesis. However, the biological functions required by c-Myc to induce oncogenesis remain elusive. Here we show that c-Myc has a direct role in the control of DNA replication. c-Myc interacts with the pre-replicative complex and localizes to early sites of DNA synthesis. Depletion of c-Myc from mammalian (human and mouse) cells as well as from Xenopus… Expand
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