Non-traditional roles for the Adenomatous Polyposis Coli (APC) tumor suppressor protein.

@article{Hanson2005NontraditionalRF,
  title={Non-traditional roles for the Adenomatous Polyposis Coli (APC) tumor suppressor protein.},
  author={Caroline A Hanson and Jeffrey R. Miller},
  journal={Gene},
  year={2005},
  volume={361},
  pages={1-12}
}
The Adenomatous Polyposis Coli (APC) tumor suppressor is a multifunctional protein that is mutated in a majority of colon cancers. The role of APC as an antagonist of the Wnt signaling pathway is well known and it is widely accepted that inappropriate activation of this pathway through loss of APC function contributes to the progression of colon cancers. However, a body of evidence is growing to support the idea that APC plays non-traditional functions outside of the Wnt pathway with roles in… CONTINUE READING

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