Non-thermal irreversible electroporation for deep intracranial disorders

@article{Garcia2010NonthermalIE,
  title={Non-thermal irreversible electroporation for deep intracranial disorders},
  author={Paulo A. Garcia and Robert E. Neal and John H. Rossmeisl and Rafael V. Davalos},
  journal={2010 Annual International Conference of the IEEE Engineering in Medicine and Biology},
  year={2010},
  pages={2743-2746}
}
  • P. A. Garcia, R. E. Neal, +1 author R. Davalos
  • Published 11 November 2010
  • Materials Science, Medicine
  • 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology
Non-thermal irreversible electroporation (N-TIRE) is a new minimally invasive technique to kill undesirable tissue. We build on our previous intracranial studies in order to evaluate the possibility of using N-TIRE for deep intracranial disorders. In this manuscript we describe a minimally invasive computed tomography (CT) guided N-TIRE procedure in white matter. In addition, we report the electric field threshold needed for white matter ablation (630 – 875 V/cm) using four sets of twenty 50 µs… Expand
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References

SHOWING 1-10 OF 12 REFERENCES
Intracranial Nonthermal Irreversible Electroporation: In Vivo Analysis
TLDR
This preliminary study provides some of the necessary numerical tools for using NTIRE as a brain cancer treatment and computed the electrical conductivity of brain tissue from the in vivo data and the numerical models to provide guidelines for treatment planning and execution. Expand
Imaging Guided Percutaneous Irreversible Electroporation: Ultrasound and Immunohistological Correlation
TLDR
Percutaneous irreversible electroporation can provide a novel and unique ablative method with real-time monitoring capability, ultra-short procedure time, non-thermal ablation, and well-controlled and focused apoptotic cell death. Expand
Tumor Ablation with Irreversible Electroporation
TLDR
The first successful use of irreversible electroporation for the minimally invasive treatment of aggressive cutaneous tumors implanted in mice was reported, and induced complete regression in 12 out of 13 treated tumors, in the absence of tissue heating. Expand
NON-THERMAL IRREVERSIBLE ELECTROPORATION
Non-thermal irreversible electroporation (IRE) is a promising new technique for the ablation of undesirable tissues, particularly tumors and arrhythmogenic regions in the heart (Davalos, Otten et al.Expand
Tissue Ablation with Irreversible Electroporation
TLDR
It is shown through mathematical analysis that irreversible electroporation can ablate substantial volumes of tissue, comparable to those achieved with other ablation techniques, without causing any detrimental thermal effects and without the need of adjuvant drugs. Expand
Mathematical Modeling of Irreversible Electroporation for Treatment Planning
  • J. Edd, R. Davalos
  • Computer Science, Medicine
  • Technology in cancer research & treatment
  • 2007
TLDR
The understanding and tools necessary to design an IRE protocol are provided and the benefit of modeling in designing treatment protocols are discussed to facilitate the translation of this new and exciting cancer therapy into clinical practice. Expand
In vivo results of a new focal tissue ablation technique: irreversible electroporation
TLDR
Results of in vivo experiments that confirm the feasibility of a new minimally invasive method for tissue ablation, irreversible electroporation (IRE), and demonstrates that IRE can become an effective method for nonthermal tissueAblation requiring no drugs. Expand
Irreversible Electroporation in Medicine
  • B. Rubinsky
  • Biology, Medicine
  • Technology in cancer research & treatment
  • 2007
This is a brief introduction to the emerging field of irreversible electroporation in medicine. Certain electrical fields when applied across a cell can have as a sole effect the permeabilization ofExpand
Electric and thermal field effects in tissue around radiofrequency electrodes.
TLDR
Pulsed RF lesioning (PRFL) produces heat bursts with temperatures in the range associated with destructive heat lesions, and produces very high electric fields that may be capable of disrupting neuronal membranes and function. Expand
Feasibility of Employing Model-Based Optimization of Pulse Amplitude and Electrode Distance for Effective Tumor Electropermeabilization
TLDR
The maximal extent of permeabilization for the particular case (electrodes, tissue) was determined with the proposed approach, which could be used for electro-gene transfer, where electric field intensities should be distributed between permeabilizing threshold and irreversible threshold. Expand
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