Non-syncytial sources of fetal DNA in transcervically recovered cell populations.

@article{Briggs1995NonsyncytialSO,
  title={Non-syncytial sources of fetal DNA in transcervically recovered cell populations.},
  author={Joe Briggs and David Miller and Judith N. Bulmer and M D Griffith-Jones and V Rame and Richard J. Lilford},
  journal={Human reproduction},
  year={1995},
  volume={10 3},
  pages={749-54}
}
We have previously shown that fetal DNA can be detected in swabs and flushings obtained from the lower uterine pole prior to the termination of pregnancy. The presence of syncytiotrophoblast vesicles in transcervically retrieved samples suggested that this distinctive placental tissue was an abundant source of fetal DNA and a valuable resource in prenatal diagnosis strategies. In a more extensive study involving 150 terminations of pregnancy between 7 and 17 weeks gestational age, 29% of… CONTINUE READING