Non-synaptic exocytosis enhanced in rat cerebellar granule neurons cultured under survival-promoting conditions.

@article{Urakubo2003NonsynapticEE,
  title={Non-synaptic exocytosis enhanced in rat cerebellar granule neurons cultured under survival-promoting conditions.},
  author={Tomoyoshi Urakubo and Keiko Tominaga-Yoshino and Akihiko Ogura},
  journal={Neuroscience research},
  year={2003},
  volume={45 4},
  pages={429-36}
}
Cultured rat cerebellar granule neurons (CGNs) are often used to analyze activity-dependent neuronal selection occurring during brain development. The CGNs survive long only when the culture medium contains a depolarizing agent. However, it is argued whether the depolarization critical for survival is of presynaptic or postsynaptic compartment. Since CGNs form no synapses among them, it is generally assumed that the latter would be the case. But it is possible that the depolarization would… CONTINUE READING