Non-surgical myocardial reduction for hypertrophic obstructive cardiomyopathy

  title={Non-surgical myocardial reduction for hypertrophic obstructive cardiomyopathy},
  author={Ulrich Sigwart},
  journal={The Lancet},
  • U. Sigwart
  • Published 22 July 1995
  • Medicine
  • The Lancet
Non-surgical septal reduction (NSSR) is a promising new therapy for the treatment of classical hypertrophic obstructive cardiomyopathy (HOCM) and emerging medium-term follow-up data suggest that the benefits are sustained with no late morbidity.
Non-surgical septum reduction in hypertrophic cardiomyopathy
A novel treatment for relief of outflow tract obstruction in hypertrophic obstructive cardiomyopathy by transluminal induction of focal septal infarction by intracoronary alcohol injection, rather than by surgical myomectomy is described.
Role of Controlled Septal Infarct in Hypertrophic Obstructive Cardiomyopathy
Nonsurgical septal reduction therapy has been shown to improve diastolic function, decrease left ventricular hypertrophy and mass, and cause changes at the cellular and molecular level that improve myocardial function.
Original paper Non-surgical septal reduction by coil embolization in patients with hypertrophic obstructive cardiomyopathy. An alternative to alcohol ablation
The presented method could be an interesting alternative for left ventricular outflow tract pressure gradient reduction in patients with HOCM in whom alcohol ablation may be related to a higher risk of complications.
The Treatment of Hypertrophic Obstructive Cardiomyopathy by Nonsurgical Myocardial Reduction
A novel treatment for hypertrophic obstructive cardiomyoparhy is described, in which septal reduction is achived via transluminal induction of focal sePTal infarction, which is well tolerated and effective in reducing the obstruction to left ventricular ourflow.
Percutaneous transluminal septal myocardial ablation: a new catheter-based therapy for patients with hypertrophic obstructive cardiomyopathy.
Percutaneous transluminal septal myocardial ablation is a catheter-based approach that involves instilling alcohol into the sePTal branches of the left anterior descending artery to induce a 'controlled' sepsis in patients with hypertrophic obstructive cardiomyopathy.
Nonsurgical septal reduction therapy for hypertrophic obstructive cardiomyopathy: Short‐term results in 50 consecutive procedures
Background: Nonsurgical septal reduction therapy (NSRT) has been shown to improve left ventricular outflow tract (LVOT) gradients, decrease septal thickness, and improve symptoms in patients with
A Case of Transcatheter Alcohol Ablation of the Septum in a Patient of Hypertrophic Obstructive Cardiomyopathy
A novel catheter-based technique that may replace surgical myocardial reduction is described that is interventional infarction of a portion of the interventricular septum by the infusion of alcohol into a selectively catheterized septal artery.
Contemporary Septal Reduction Therapy in Drug-Refractory Hypertrophic Obstructive Cardiomyopathy.
This review will focus on the emerging concept and practical implication of SRT and the available evidence on either PTSMA or surgical myectomy in the literature.


Current operative treatment of obstructive hypertrophic cardiomyopathy.
The experiences gained from the clinical appraisal of patients during a long period of time, as well as from technical advances in echocardiographic techniques, have considerably enhanced the understanding of the role of operation in HCM and have altered concepts regarding the intraoperative management of such patients.
[Hypertrophic obstructive cardiomyopathy: surgical therapy].
To date, follow-up show an improvement in the symptoms and physical performance, and an annual mortality rate of about 1.8-4% among patients treated with drugs, and a post-operative mortality ofAbout 1.1%, so that in HOCM patients with symptoms despite prior drug treatment, surgery can be recommended.
Impact of Dual‐Chamber Permanent Pacing in Patients With Obstructive Hypertrophic Cardiomyopathy With Symptoms Refractory to Verapamil and β‐Adrenergic Blocker Therapy
DDD pacing is an effective alternative to surgery in most patients with obstructive HCM with drug-refractory symptoms and the beneficial effects of pacing continue to be evident when pacing is acutely discontinued.
Pacing for obstructive hypertrophic cardiomyopathy.
Pacing reduced the pressure gradient in hypertrophic obstructive cardiomyopathy and that this had long-term clinical benefits was reported, and several groups have reported short-term and longterm improvement in haemodynamic and clinic variables after pacemaker treatment of hypertrophic cardiopathy.
Mitral valve replacement and septal myomectomy in hypertrophic cardiomyopathy. Ten-year follow-up in 80 patients.
The findings indicate that, in patients with hypertrophic cardiomyopathy who require surgical treatment, MVR alone or in conjunction with septal myomectomy offers significant improvement of symptoms and hemodynamic values.