Non-suppression of cortisol secretion by long term treatment with ketoconazole in patients with acute leukaemia.

Abstract

Ketoconazole, a potent antifungal agent, inhibits adrenal steroidogenesis in normal subjects during short term treatment. Since this drug is used in the long term prophylaxis of fungal infections in patients with haematological malignancies, we have investigated whether such patients have evidence of adrenocortical suppression. Six patients on long term… (More)

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@article{Dandona1985NonsuppressionOC, title={Non-suppression of cortisol secretion by long term treatment with ketoconazole in patients with acute leukaemia.}, author={Paresh Dandona and Jahan J. Mohiuddin and H. Grant Prentice}, journal={Journal of clinical pathology}, year={1985}, volume={38 6}, pages={677-8} }