Non-steroidal anti-inflammatory drugs and renal response to exercise: a comparison of indomethacin and nabumetone.

@article{Olsen1999NonsteroidalAD,
  title={Non-steroidal anti-inflammatory drugs and renal response to exercise: a comparison of indomethacin and nabumetone.},
  author={Niels Vidiendal Olsen and N G Jensen and Jesper Melchior Hansen and Niels Juel Christensen and Niels Fogh‐Andersen and I. L. Kanstrup},
  journal={Clinical science},
  year={1999},
  volume={97 4},
  pages={
          457-65
        }
}
Nabumetone, a newer non-steroidal anti-inflammatory drug (NSAID) which preferentially blocks cyclo-oxygenase-2 activity, may be less nephrotoxic than indomethacin. This study tested whether nabumetone has effects different from those of indomethacin on exercise-induced changes in renal function and the renin-aldosterone system. In a randomized fashion, ten subjects were studied after indomethacin (100 mg), nabumetone (1 g) or no medication (control) administered orally at 22.00 hours on the day… 

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Nonsteroidal antiinflammatory drugs (NSAID) decrease renal prostaglandins and may cause a decrease in renal blood flow, glomerular filtration, and sodium excretion. In some cases, these effects
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