Non-steroidal anti-inflammatory drugs and platelet function.

  title={Non-steroidal anti-inflammatory drugs and platelet function.},
  author={E. Garth McQueen and B D Facoory and Jim M Faed},
  journal={The New Zealand medical journal},
  volume={99 802},
The effect of some newer non steroidal inflammatory drugs on platelet function has been assessed using platelet malondialdehyde production as a measure of cyclooxygenase activity. After single doses of the short acting NSAID's diflunisal, naproxen and sulindac, platelet malondialdehyde production was substantially diminished at one and three hours. It had largely recovered by 24 hours and had returned to normal by 48 hours. After aspirin malondialdehyde production was markedly reduced and was… CONTINUE READING