Non-steroidal anti-inflammatory drugs (NSAIDs) associate with zwitterionic phospholipids: Insight into the mechanism and reversal of NSAID-induced gastrointestinal injury

@article{Lichtenberger1995NonsteroidalAD,
  title={Non-steroidal anti-inflammatory drugs (NSAIDs) associate with zwitterionic phospholipids: Insight into the mechanism and reversal of NSAID-induced gastrointestinal injury},
  author={Lenard M. Lichtenberger and Zu-Mo Wang and Jimmy J. Romero and Carlos Ulloa and J Christian P{\'e}rez and M D Giraud and Jos{\'e} C. Barreto},
  journal={Nature Medicine},
  year={1995},
  volume={1},
  pages={154-158}
}
The molecular basis of the injurious actions of non-steroidal anti-inflammatory drugs (NSAIDs) on the gastrointestinal (GI) tract is only partly understood. In this study we have obtained evidence, employing both in vitro and in vivo systems, that five NSAIDs have the ability to form a chemical association with zwitterionic phospholipids. Since this same class of phospholipids line the luminal aspects of the mucus gel layer to provide it with non-wettable properties, this intermolecular… CONTINUE READING

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