Non-steroidal anti-inflammatory drugs: panacea or poison?

@article{Pope2015NonsteroidalAD,
  title={Non-steroidal anti-inflammatory drugs: panacea or poison?},
  author={C. Pope and R. Spacie and William Mackintosh},
  journal={InnovAiT},
  year={2015},
  volume={8},
  pages={178 - 183}
}
Non-steroidal anti-inflammatory drugs (NSAIDs) form an integral part of the World Health Organization’s (WHO's) pain ladder and in 2012 over 4 500 000 prescriptions for ibuprofen were dispensed in England alone. However, several NSAIDs have now been withdrawn from the market due to concerns about cardiovascular risk. Given their widespread use, but well-documented serious side effects, what exactly are NSAIDs, when should they be used, and how can the risk to your patients be minimised? 

References

SHOWING 1-7 OF 7 REFERENCES
Non-steroidal anti-inflammatory drugs (NSAIDs)
  • Y. Miura
  • Medicine
  • Nihon rinsho. Japanese journal of clinical medicine
  • 1995
TLDR
For Patients With “Step Therapy” (generic before brand) ONLY: Based on review of available data, the Company may consider brand name non-steroidal anti-inflammatory drugs (NSAIDs) to be eligible for coverage when one of the below patient selection criteria is met. Expand
Non-steroidal anti-inflammatory drugs (NSAIDs)
A 70 year old obese woman asks if more can be done for her knee and low back pain, due to osteoarthritis. She used to smoke and has type 2 diabetes. Her orthopaedic surgeon does not consider theExpand
Evidence for the Use of Non-Steroidal Anti-Inflammatory Drugs for Acute Pain in the Post Anaesthesia Care Unit
TLDR
The evidence for the use of non-steroidal anti-inflammatory drugs (NSAIDs) for acute postoperative pain is considered. Expand
Combining Paracetamol (Acetaminophen) with Nonsteroidal Antiinflammatory Drugs: A Qualitative Systematic Review of Analgesic Efficacy for Acute Postoperative Pain
TLDR
Current evidence suggests that a combination of paracetamol and an NSAID may offer superior analgesia compared with either drug alone. Expand
TRPA1 mediates spinal antinociception induced by acetaminophen and the cannabinoid Δ(9)-tetrahydrocannabiorcol.
TLDR
The antinociceptive effects of spinal and systemic administration of acetaminophen are shown to be lost in Trpa1(-/-) mice and spinal TRPA1 activation is disclosed as a potential pharmacological strategy to alleviate pain. Expand
Bill Frankland: active allergist at 101
How many people use retail analgesics ?
  • 2002