Non-steroidal anti-inflammatory drug-induced small intestinal damage is Toll-like receptor 4 dependent.

@article{Watanabe2008NonsteroidalAD,
  title={Non-steroidal anti-inflammatory drug-induced small intestinal damage is Toll-like receptor 4 dependent.},
  author={Toshio Watanabe and Kazuhide Higuchi and Atsushi Kobata and Hikaru Nishio and Tetsuya Tanigawa and Masatsugu Shiba and K Tominaga and Yasuhiro Fujiwara and Nobuhide Oshitani and Takashi Asahara and Koji Nomoto and Koji Takeuchi and Tetsuo Arakawa},
  journal={Gut},
  year={2008},
  volume={57 2},
  pages={181-7}
}
BACKGROUND Enterobacteria and cytokines both play roles in the pathophysiology of NSAID-induced enteropathy. Toll-like receptor (TLR) 4 recognises lipopolysaccharide (LPS), resulting in activation of an inflammatory cascade via the accessory protein MyD88. AIMS To investigate role of TLR4 in inflammatory responses in indomethacin-induced enteropathy. METHODS Indomethacin was administered p.o. to non-fasting rats and mice to induce small intestinal damage. The extent of such damage was… CONTINUE READING

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