Non-specific serum iron in thalassaemia: an abnormal serum iron fraction of potential toxicity.

  title={Non-specific serum iron in thalassaemia: an abnormal serum iron fraction of potential toxicity.},
  author={Chaim Hershko and Gerard Graham and Gordon Wright Bates and Eliezer A. Rachmilewitz},
  journal={British journal of haematology},
  volume={40 2},
Iron binding in the sera of 35 patients with beta thalassaemia major and intermedia was studied. In patients receiving regular blood transfusions since infancy transferrin was completely saturated and about 2.7--7.1 mumol/l of the serum iron could be removed by dialysis or ultrafiltration in the presence of a chelating agent or by filtration on DEAE-Sephadex-catecholdisulphonic acid columns. In contrast, less than 1.0 mumol/l of transferrin bound iron was removed when subjected to the same… CONTINUE READING
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