Non-solid oncogenes in solid tumors: EML4-ALK fusion genes in lung cancer.

@article{Mano2008NonsolidOI,
  title={Non-solid oncogenes in solid tumors: EML4-ALK fusion genes in lung cancer.},
  author={Hiroyuki Mano},
  journal={Cancer science},
  year={2008},
  volume={99 12},
  pages={2349-55}
}
It is generally accepted that recurrent chromosome translocations play a major role in the molecular pathogenesis of hematological malignancies but not of solid tumors. However, chromosome translocations involving the e26 transformation-specific sequence transcription factor loci have been demonstrated recently in many prostate cancer cases. Furthermore, through a functional screening with retroviral cDNA expression libraries, we have discovered the fusion-type protein tyrosine kinase… CONTINUE READING
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