Non-small cell lung cancer: c-erbB-2 overexpression correlates with low angiogenesis and poor prognosis.

@article{Giatromanolaki1996NonsmallCL,
  title={Non-small cell lung cancer: c-erbB-2 overexpression correlates with low angiogenesis and poor prognosis.},
  author={Alexandra N Giatromanolaki and Michael I. Koukourakis and Kenneth J O'byrne and Loukas Kaklamanis and C C Dicoglou and E Trichia and R. M. Whitehouse and Adrian L. Harris and Kevin C. Gatter},
  journal={Anticancer research},
  year={1996},
  volume={16 6B},
  pages={3819-25}
}
Tumour angiogenesis is an important prognostic factor in non-small cell lung cancer. Recently, EGFR and c-erbB-2 protein was found to regulate cell adhesion and the invasive growth of cancer through its association with the cadherin-catenin complex. The role of c-erbB-2 protein in cell migration has been also reported. In this study we investigate the combined role of tumoral neoangiogenesis and c-erbB-2/EGFR expression in the metastatic behaviour and prognosis of operable non-small cell lung… CONTINUE READING

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