Non-small Cell Lung Cancer Cyclooxygenase-2-dependent Invasion Is Mediated by CD44*

  title={Non-small Cell Lung Cancer Cyclooxygenase-2-dependent Invasion Is Mediated by CD44*},
  author={M. Dohadwala and J. Luo and L. Zhu and Y. Lin and G. Dougherty and S. Sharma and M. Huang and M. Pǒld and R. K. Batra and S. Dubinett},
  journal={The Journal of Biological Chemistry},
  pages={20809 - 20812}
  • M. Dohadwala, J. Luo, +7 authors S. Dubinett
  • Published 2001
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • Elevated tumor cyclooxygenase (COX-2) expression is associated with increased angiogenesis, tumor invasion, and suppression of host immunity. We have previously shown that genetic inhibition of tumor COX-2 expression reverses the immunosuppression induced by non-small cell lung cancer (NSCLC). To assess the impact of COX-2 expression in lung cancer invasiveness, NSCLC cell lines were transduced with a retroviral vector expressing the human COX-2 cDNA in the sense (COX-2-S) and antisense (COX-2… CONTINUE READING
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