Non-serotonergic pharmacological profiles and associated cognitive effects of serotonin reuptake inhibitors

  title={Non-serotonergic pharmacological profiles and associated cognitive effects of serotonin reuptake inhibitors},
  author={Jeroen A. J. Schmitt and Monique J. Kruizinga and Wim J. Riedel},
  journal={Journal of Psychopharmacology},
  pages={173 - 179}
The current study was carried out to investigate the cognitive effects of two serotonin reuptake inhibitors (SSRIs), sertraline and paroxetine, with special reference to differences in their affinity for other neurotransmitter systems, i.e. anticholinergic activity of paroxetine and putative dopamine reuptake activity of sertraline. The study was conducted according to a double-blind, three-way cross-over design. During three treatment periods of 2 weeks, 24 healthy middle-aged (aged 30–50… 

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