Non-repair pathways for minimizing protein isoaspartyl damage in the yeast Saccharomyces cerevisiae.

@article{Patananan2014NonrepairPF,
  title={Non-repair pathways for minimizing protein isoaspartyl damage in the yeast Saccharomyces cerevisiae.},
  author={Alexander Nikolich Patananan and Joseph R Capri and Julian P Whitelegge and Steven G. Clarke},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 24},
  pages={16936-53}
}
The spontaneous degradation of asparaginyl and aspartyl residues to isoaspartyl residues is a common type of protein damage in aging organisms. Although the protein-l-isoaspartyl (d-aspartyl) O-methyltransferase (EC 2.1.1.77) can initiate the repair of l-isoaspartyl residues to l-aspartyl residues in most organisms, no gene homolog or enzymatic activity is… CONTINUE READING