Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response

  title={Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response},
  author={Cecilia Garlanda and Emilio Hirsch and Silvia Bozza and Antonietta Salustri and Marika De Acetis and Rachele Nota and Alessia Maccagno and Federica Riva and Barbara Bottazzi and Giuseppe Peri and Andrea Doni and Luca Vago and Marina Botto and Rita De Santis and Paolo Carminati and Gregorio Siracusa and Fiorella Altruda and Annunciata Vecchi and Luigina Romani and Alberto Mantovani},
Pentraxins are a superfamily of conserved proteins that are characterized by a cyclic multimeric structure. The classical short pentraxins, C-reactive protein (CRP) and serum amyloid P component (SAP), are acute-phase proteins produced in the liver in response to inflammatory mediators. Short pentraxins regulate innate resistance to microbes and the scavenging of cellular debris and extracellular matrix components. In contrast, long pentraxins have an unrelated, long amino-terminal domain… CONTINUE READING
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