Non-random subcellular distribution of variant EKLF in erythroid cells.

@article{Quadrini2008NonrandomSD,
  title={Non-random subcellular distribution of variant EKLF in erythroid cells.},
  author={Karen J Quadrini and Eugenia Gruzglin and James J Bieker},
  journal={Experimental cell research},
  year={2008},
  volume={314 7},
  pages={1595-604}
}
EKLF protein plays a prominent role during erythroid development as a nuclear transcription factor. Not surprisingly, exogenous EKLF quickly localizes to the nucleus. However, using two different assays we have unexpectedly found that a substantial proportion of endogenous EKLF resides in the cytoplasm at steady state in all erythroid cells examined. While EKLF localization does not appear to change during either erythroid development or terminal differentiation, we find that the protein… CONTINUE READING