Non-random, individual-specific methylation profiles are present at the sixth CTCF binding site in the human H19/IGF2 imprinting control region.

@inproceedings{Tost2007NonrandomIM,
  title={Non-random, individual-specific methylation profiles are present at the sixth CTCF binding site in the human H19/IGF2 imprinting control region.},
  author={J{\"o}rg Tost and H Jammes and J M Dupont and Christophe Buffat and Brigitte Robert and T. M. Mignot and Françoise Mondon and B. Carbonne and Umberto Sim{\'e}oni and Gilles Grange and Antoine Kerjean and Françoise Ferr{\'e} and Ivo G Gut and Daniel Vaiman},
  booktitle={Nucleic acids research},
  year={2007}
}
After publication of the article, it has been brought to our attention by Dr. Richard Scott and Prof. Nazneen Rahman at the Institute of Cancer Research (Sutton, UK) that the observed three profiles and their heritability could be fully explained by a biased amplification caused by an SNP (rs2107425) underlying the 21st of 24 bases (calculated from the 30 terminus) of the reverse primer. Biased amplification due to a SNP so close to the 50 end of an amplification primer is astonishing, the more… CONTINUE READING

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