Non-racemic mixture model: a computational approach.

  title={Non-racemic mixture model: a computational approach.},
  author={C. Polanco and T. Buhse},
  journal={Acta biochimica Polonica},
  volume={64 1},
The behavior of a slight chiral bias in favor of l-amino acids over d-amino acids was studied in an evolutionary mathematical model generating mixed chiral peptide hexamers. The simulations aimed to reproduce a very generalized prebiotic scenario involving a specified couple of amino acid enantiomers and a possible asymmetric amplification through autocatalytic peptide self-replication while forming small multimers of a defined length. Our simplified model allowed the observation of a small… Expand


A toy model of prebiotic peptide evolution: the possible role of relative amino acid abundances.
A mathematical-computational toy model based on the assumed dynamic principles of prebiotic peptide evolution suggests that the relative amino acid abundances, as indicated by Miller-Urey type electric discharge experiments, played a principal role in the early sequential information of peptide profiles. Expand
Spontaneous Onset of Homochirality in Oligopeptide Chains Generated in the Polymerization of N-Carboxyanhydride Amino Acids in Water
  • T. Hitz, P. Luisi
  • Chemistry, Medicine
  • Origins of life and evolution of the biosphere
  • 2004
It is shown that the polymerization of hydrophobic NCA in aqueous solution yields oligopeptides that are characterized by a high degree of homochiral sequences, and thinks that such processes are relevant to the chemical evolution of single handedness. Expand
Enantiomeric Excesses in Meteoritic Amino Acids
Gas chromatographic-mass spectral analyses of the four stereoisomers of 2-amino-2,3-dimethylpentanoic acid obtained from the Murchison meteorite show that the L enantiomer occurs in excess, indicative of an asymmetric influence on organic chemical evolution before the origin of life. Expand
Selective adsorption and chiral amplification of amino acids in vermiculite clay-implications for the origin of biochirality.
The results show that during reaction with fresh vermiculite interlayers, significant chiral enrichment of either L- and D-enantiomers occurs depending on the amino acid, suggesting that such chiral separation by clays in lagoonal environments at normal biological temperatures might also have played a significant role in the origin of biochirality. Expand
The design of self-replicating helical peptides.
The self-assembly of helical peptides and information transfer through autocatalysis and cross-catalysis are the foundation of peptide-based molecular evolution models and many fundamental properties of living systems are exhibited by various self-replicating peptide systems. Expand
Amino acids from ultraviolet irradiation of interstellar ice analogues
The results demonstrate that the spontaneous generation of amino acids in the interstellar medium is possible, supporting the suggestion that prebiotic molecules could have been delivered to the early Earth by cometary dust, meteorites or interplanetary dust particles. Expand
Toy models for macroevolutionary patterns and trends
This paper examines thirteen models which describe evolution that also qualify as toy models, including the tree of life, branching processes, adaptive ratchets, fitness landscapes, and the role of nonlinear avalanches in evolutionary dynamics. Expand
A production of amino acids under possible primitive earth conditions.
In this study, an apparatus was built to circulate CHI4, NH3, H2O, and H2 past an electric discharge, and the resulting mixture has been tested for amino acids by paper chromatography. Expand
Recovery of Cometary Microorganisms from the Stratosphere
The Hoyle-Wickramasinghe theory of cometary panspermia posits that terrestrial life was introduced by comets, and predicts that this process can be tested by the detection of an ongoing incidenceExpand
On spontaneous asymmetric synthesis.
  • F. Frank
  • Chemistry, Medicine
  • Biochimica et biophysica acta
  • 1953
Abstract The kinetic equations of growth of symmetrically mutually antagonistic self-reproducing systems are considered and shown to lead to instability. It follows that spontaneous asymmetricExpand