Non-psychoactive CB2 cannabinoid agonists stimulate neural progenitor proliferation.

@article{Palazuelos2006NonpsychoactiveCC,
  title={Non-psychoactive CB2 cannabinoid agonists stimulate neural progenitor proliferation.},
  author={Javier Palazuelos and Tania Aguado and Ainara Egia and Raphael Mechoulam and Manuel Alejandro P{\'e}rez Guzm{\'a}n and Ismael Galve-Roperh},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2006},
  volume={20 13},
  pages={
          2405-7
        }
}
Cannabinoids, the active components of marijuana and their endogenous counterparts, act on the brain and many other organs through the widely expressed CB1 cannabinoid receptor. In contrast, the CB2 cannabinoid receptor is abundant in the immune system and shows a restricted expression pattern in brain cells. CB2-selective agonists are, therefore, very attractive therapeutic agents as they do not cause CB1-mediated psychoactive effects. CB2 receptor expression in brain has been partially… CONTINUE READING

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