Non-peptide gonadotropin-releasing hormone receptor antagonists.

@article{Betz2008NonpeptideGH,
  title={Non-peptide gonadotropin-releasing hormone receptor antagonists.},
  author={Stephen F. Betz and Y Zhu and Chen Chen and Raymond Struthers},
  journal={Journal of medicinal chemistry},
  year={2008},
  volume={51 12},
  pages={3331-48}
}
Introduction Gonadotropin-releasing hormone (GnRH) is the principal neuroendocrine regulator of the reproductive system in humans. It is a linear decapeptide, pGlu-His-Trp-Ser-Tyr-Gly-Leu-ArgPro-Gly-NH2, that was first isolated from porcine and ovine hypothalamii. This peptide and related isoforms have subsequently been identified in a wide range of species, indicating that core features of the sequence have been conserved over ∼600 million years of chordate evolution. The GnRH peptide is made… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 130 references

A Useful Oral Bioavailability / Plasma Exposure Model for 4 - ( 2 - Phenyl ) benzimidazole GnRH Antagonists Based on a Narrow Set of Physico - Chemical Molecular Properties

  • J. C. Pelletier, D. M. Green, M. V. Chengalvala, I. B. Feingold, C. Huselton
  • 2006

Similar Papers

Loading similar papers…