Non-peptide gonadotropin-releasing hormone receptor antagonists.

  title={Non-peptide gonadotropin-releasing hormone receptor antagonists.},
  author={Stephen F. Betz and Y Zhu and Chen Chen and Raymond Struthers},
  journal={Journal of medicinal chemistry},
  volume={51 12},
Introduction Gonadotropin-releasing hormone (GnRH) is the principal neuroendocrine regulator of the reproductive system in humans. It is a linear decapeptide, pGlu-His-Trp-Ser-Tyr-Gly-Leu-ArgPro-Gly-NH2, that was first isolated from porcine and ovine hypothalamii. This peptide and related isoforms have subsequently been identified in a wide range of species, indicating that core features of the sequence have been conserved over ∼600 million years of chordate evolution. The GnRH peptide is made… CONTINUE READING


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A Useful Oral Bioavailability / Plasma Exposure Model for 4 - ( 2 - Phenyl ) benzimidazole GnRH Antagonists Based on a Narrow Set of Physico - Chemical Molecular Properties

  • J. C. Pelletier, D. M. Green, M. V. Chengalvala, I. B. Feingold, C. Huselton
  • 2006

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