Non-peptide bombesin receptor antagonists, kuwanon G and H, isolated from mulberry.

@article{Mihara1995NonpeptideBR,
  title={Non-peptide bombesin receptor antagonists, kuwanon G and H, isolated from mulberry.},
  author={Saori Mihara and Masaki Hara and Machiko Nakamura and K Sakurawi and K Tokura and Masafumi Fujimoto and Toshio Fukai and Taisei Nomura},
  journal={Biochemical and biophysical research communications},
  year={1995},
  volume={213 2},
  pages={594-9}
}
Kuwanon G and H, isolated from the methanol extract of Morus bombycis, inhibited specific binding of [125I]gastrin-releasing peptide (GRP) to GRP-preferring receptors in murine Swiss 3T3 fibroblasts with Ki values of 470 and 290 nM, respectively. Kuwanon H was one order of magnitude less potent for inhibiting [125I]bombesin binding to neuromedin B (NMB)-preferring receptors in rat esophagus membranes. This compound antagonized bombesin-induced increases in the cytosolic free calcium… CONTINUE READING

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