Non-nicotinic neuropharmacological strategies for nicotine dependence: beyond bupropion.

  title={Non-nicotinic neuropharmacological strategies for nicotine dependence: beyond bupropion.},
  author={John F Cryan and Fabrizio Gasparini and Gino van Heeke and Athina Markou},
  journal={Drug discovery today},
  volume={8 22},
Smoking is a major health problem and is propelled, at least in part, by the addictive properties of nicotine. Two types of pharmacological therapies have been approved for smoking cessation by the US Food and Drug Administration. The first therapy consists of nicotine replacement, substituting the nicotine from cigarettes with safer nicotine formulations. The second therapy is bupropion (Zyban), an atypical antidepressant, whose use has raised much debate as to how a non-nicotine-based agent… CONTINUE READING
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