Non-neutral evolution and reciprocal monophyly of two expressed Mhc class II B genes in Leach’s storm-petrel

@article{Dearborn2014NonneutralEA,
  title={Non-neutral evolution and reciprocal monophyly of two expressed Mhc class II B genes in Leach’s storm-petrel},
  author={Donald C Dearborn and Andrea B. Gager and Morgan E. Gilmour and Andrew G. McArthur and Douglas A. Hinerfeld and Robert A Mauck},
  journal={Immunogenetics},
  year={2014},
  volume={67},
  pages={111-123}
}
The major histocompatibility complex (Mhc) is subject to pathogen-mediated balancing selection and can link natural selection with mate choice. We characterized two Mhc class II B loci in Leach’s storm-petrel, Oceanodroma leucorhoa, focusing on exon 2 which encodes the portion of the protein that binds pathogen peptides. We amplified and sequenced exon 2 with locus-specific nested PCR and Illumina MiSeq using individually barcoded primers. Repeat genotyping of 78 single-locus genotypes produced… CONTINUE READING
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