Non-neuronal release of ATP and inositol 1,4,5-trisphosphate accumulation evoked by P2- and M-receptor stimulation in guinea pig ileal segments.

@article{Katsuragi1996NonneuronalRO,
  title={Non-neuronal release of ATP and inositol 1,4,5-trisphosphate accumulation evoked by P2- and M-receptor stimulation in guinea pig ileal segments.},
  author={Takeshi Katsuragi and Katsuhisa Matsuo and Chu Sato and Kazuo Honda and Hiro-o Kamiya and Tatsuo Furukawa},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1996},
  volume={277 2},
  pages={747-52}
}
Intracellular signal transduction involved in non-neuronal ATP release evoked by alpha, beta-methylene ATP and bethanechol was evaluated in guinea pig ileal longitudinal muscle segments. alpha, beta-methylene ATP (100 microM) and bethanechol (10 microM) evoked ATP released that reached a peak about 3 min after administration. The evoked release of ATP was markedly inhibited by neomycin and spermine, inhibitors of phospholipase C, but not by treatment with pertussis toxin. In addition, the… CONTINUE READING
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