Non-natural amino acids for tumor imaging using positron emission tomography and single photon emission computed tomography

@article{McConathy2008NonnaturalAA,
  title={Non-natural amino acids for tumor imaging using positron emission tomography and single photon emission computed tomography},
  author={Jonathan E McConathy and Mark M. Goodman},
  journal={Cancer and Metastasis Reviews},
  year={2008},
  volume={27},
  pages={555-573}
}
Amino acids are required nutrients for proliferating tumor cells, and amino acid transport is upregulated in many tumor types. Studies of radiolabeled amino acids in animals and humans demonstrate that amino acid based tracers have advantageous characteristics relative to 2-[18F]fluoro-2-deoxyglucose in certain tumors, particularly brain gliomas. Non-natural amino acids for tumor imaging generally have greater metabolic stability and can be labeled with longer-lived radionuclides for positron… CONTINUE READING

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