Non-myeloablative hematopoietic stem cell transplantation for the treatment of adult T-cell lymphoma in a patient with advanced hepatic impairment.

@article{Hamaki2003NonmyeloablativeHS,
  title={Non-myeloablative hematopoietic stem cell transplantation for the treatment of adult T-cell lymphoma in a patient with advanced hepatic impairment.},
  author={Tamae Hamaki and Masahiro Kami and Masahiro Igarashi and Eiji Kusumi and Yasuji Arase and Toru Ishibashi and Kenji Shimamura and Shigesaburo Miyakoshi and Shin-ichi Morinaga and Yoichi Takaue and Masahiro Hayashi and Yoshitomo Mutou},
  journal={Leukemia & lymphoma},
  year={2003},
  volume={44 4},
  pages={703-8}
}
A 59-year-old man with liver cirrhosis due to hepatitis B virus infection received non-myeloablative stem-cell transplantation (NST) for the treatment of adult T-cell lymphoma. The preparative regimen consisted of cyclophosphamide and fludarabine. While the pharmacokinetics of these drugs was altered in this patient, his clinical course was uneventful without the development of severe hepatic damage. Complete remission was achieved on day 56. Although he finally died of hemorrhage from… CONTINUE READING