Non-myeloablative autologous haematopoietic stem cell transplantation expands regulatory cells and depletes IL-17 producing mucosal-associated invariant T cells in multiple sclerosis.

@article{Abrahamsson2013NonmyeloablativeAH,
  title={Non-myeloablative autologous haematopoietic stem cell transplantation expands regulatory cells and depletes IL-17 producing mucosal-associated invariant T cells in multiple sclerosis.},
  author={Sofia V Abrahamsson and Daniela Francesca Angelini and Amy N. Dubinsky and Esther Morel and Unsong Oh and Joanne L Jones and D Carassiti and Richard Reynolds and Marco Salvetti and Peter A. Calabresi and Alasdair John Coles and Luca Battistini and Roland Martin and Richard K. Burt and Paolo Antonio Muraro},
  journal={Brain : a journal of neurology},
  year={2013},
  volume={136 Pt 9},
  pages={2888-903}
}
Autologous haematopoietic stem cell transplantation has been tried as one experimental strategy for the treatment of patients with aggressive multiple sclerosis refractory to other immunotherapies. The procedure is aimed at ablating and repopulating the immune repertoire by sequentially mobilizing and harvesting haematopoietic stem cells, administering an immunosuppressive conditioning regimen, and re-infusing the autologous haematopoietic cell product. 'Non-myeloablative' conditioning regimens… CONTINUE READING
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