Non-muscle myosin II in disease: mechanisms and therapeutic opportunities

  title={Non-muscle myosin II in disease: mechanisms and therapeutic opportunities},
  author={Karen A. Newell-Litwa and Rick Horwitz and Marcelo Lazzaron Lamers},
  booktitle={Disease models & mechanisms},
The actin motor protein non-muscle myosin II (NMII) acts as a master regulator of cell morphology, with a role in several essential cellular processes, including cell migration and post-synaptic dendritic spine plasticity in neurons. NMII also generates forces that alter biochemical signaling, by driving changes in interactions between actin-associated proteins that can ultimately regulate gene transcription. In addition to its roles in normal cellular physiology, NMII has recently emerged as a… CONTINUE READING
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