Non-motor parkinsonian pathology in aging A53T α-Synuclein mice is associated with progressive synucleinopathy and altered enzymatic function

@inproceedings{Farrell2014NonmotorPP,
  title={Non-motor parkinsonian pathology in aging A53T α-Synuclein mice is associated with progressive synucleinopathy and altered enzymatic function},
  author={Kaitlin F Farrell and Sesha Krishnamachari and Ernesto Villanueva and Haiyan Lou and Tshianda N. M. Alerte and Eloise Peet and Robert E Drolet and Ruth G. Perez},
  booktitle={Journal of neurochemistry},
  year={2014}
}
Aging, the main risk factor for Parkinson's disease (PD), is associated with increased α-synuclein levels in substantia nigra pars compacta (SNc). Excess α-synuclein spurs Lewy-like pathology and dysregulates the activity of protein phosphatase 2A (PP2A). PP2A dephosphorylates many neuroproteins, including the catecholamine rate-limiting enzyme, tyrosine hydroxylase (TH). A loss of nigral dopaminergic neurons induces PD movement problems, but before those abnormalities occur, behaviors such as… CONTINUE READING