Non-metabolic functions of glycolytic enzymes in tumorigenesis

  title={Non-metabolic functions of glycolytic enzymes in tumorigenesis},
  author={Xianjun Yu and Shuo Li},
Cancer cells reprogram their metabolism to meet the requirement for survival and rapid growth. One hallmark of cancer metabolism is elevated aerobic glycolysis and reduced oxidative phosphorylation. Emerging evidence showed that most glycolytic enzymes are deregulated in cancer cells and play important roles in tumorigenesis. Recent studies revealed that all essential glycolytic enzymes can be translocated into nucleus where they participate in tumor progression independent of their canonical… CONTINUE READING
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