Non-melanoma skin cancer: carcinogenesis and chemoprevention.

@article{Chen2013NonmelanomaSC,
  title={Non-melanoma skin cancer: carcinogenesis and chemoprevention.},
  author={Andrew C Chen and Gary M Halliday and Diona L. Damian},
  journal={Pathology},
  year={2013},
  volume={45 3},
  pages={
          331-41
        }
}
Non-melanoma skin cancer (NMSC) is by far the most frequently diagnosed cancer in Australia, and exposure to ultraviolet (UV) radiation is the primary cause. Both UVB and UVA radiation have been shown to cause DNA damage and immunosuppression, the important forms of biological damage that lead to NMSC. The DNA of keratinocytes absorbs UV radiation and produces photolesions such as cyclobutane pyrimidine dimers (CPDs). UV absorption by other chromophores results in the production of reactive… CONTINUE READING
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