Non-malignant leukocytes delay spontaneous B-CLL cell apoptosis

@article{Gamberale2001NonmalignantLD,
  title={Non-malignant leukocytes delay spontaneous B-CLL cell apoptosis},
  author={Romina Gamberale and Jorge Ra{\'u}l Geffner and Guillermo Arrosagaray and Mariano Scolnik and Gabriela Ver{\'o}nica Salamone and Anal{\'i}a S Trevani and M{\'o}nica Vermeulen and Mirta Nilda Giordano},
  journal={Leukemia},
  year={2001},
  volume={15},
  pages={1860-1867}
}
Malignant B cells from chronic lymphocytic leukemia (B-CLL) patients have a long survival in vivo, although, in culture, they spontaneously die by apoptosis. Here, we analyzed the capacity of accessory leukocytes to modulate apoptosis of B-CLL cells in vitro. To this end, we performed long-term cultures using total mononuclear cells (TMC) from B-CLL patients and TMC depleted from monocytes, NK cells and T lymphocytes (B-CLL cells). In all the patients studied (n = 25) the presence of accessory… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

Similar Papers

Loading similar papers…