Non-lysosomal degradation of misfolded human lysozymes with and without an asparagine-linked glycosylation site.


Human lysozyme is a monomeric secretory protein composed of 130 amino acid residues, with four intramolecular disulfide bonds and no oligosaccharides. In this study, a mutant protein, [Ala128] lysozyme, which cannot fold because it lacks a disulfide bond, Cys6-Cys128, was expressed in mouse fibroblasts and was found to be mostly degraded in the cells… (More)


Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.