Non-invasive therapy to reduce the body burden of aluminium in Alzheimer's disease.

@article{Exley2006NoninvasiveTT,
  title={Non-invasive therapy to reduce the body burden of aluminium in Alzheimer's disease.},
  author={Christopher Exley and Olga V. Korchazhkina and Deborah Job and Stanislav Strekopytov and Anthony Polwart and Peter Crome},
  journal={Journal of Alzheimer's disease : JAD},
  year={2006},
  volume={10 1},
  pages={
          17-24; discussion 29-31
        }
}
There are unexplained links between human exposure to aluminium and the incidence, progression and aetiology of Alzheimer's disease. The null hypothesis which underlies any link is that there would be no Alzheimer's disease in the effective absence of a body burden of aluminium. To test this the latter would have to be reduced to and retained at a level that was commensurate with an Alzheimer's disease-free population. In the absence of recent human interference in the biogeochemical cycle of… 

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References

SHOWING 1-10 OF 25 REFERENCES
Intramuscular desferrioxamine in patients with Alzheimer's disease
Elevated urinary excretion of aluminium and iron in multiple sclerosis
TLDR
Urinary concentrations of aluminium were significantly increased in RRMS and SPMS such that the levels of aluminium excretion in the former were similar to those observed in individuals undergoing metal chelation therapy, and increased excretion of iron in urine supported a role for iron dysmetabolism in MS.
Relation between aluminum concentrations in drinking water and Alzheimer's disease: an 8-year follow-up study.
TLDR
Findings support the hypothesis that a high concentration of aluminum in drinking water may be a risk factor for Alzheimer's disease.
Effect of silicon on gastrointestinal absorption of aluminium
Cognitive impairment and composition of drinking water in women: findings of the EPIDOS Study.
TLDR
A multivariate analysis including potential confounding factors showed that women with AD appeared to have been exposed to lower amounts of silica at baseline, which corroborate those of another epidemiologic study carried out in France.
The role of silicic acid in the renal excretion of aluminium.
TLDR
Silicic acid's effect on the depletion of aluminium stores and reduced GI absorption suggest its addition to municipal water supplies may be a low risk public health measure to reduce the AI burden in the general population.
Acute toxicity of aluminium to fish eliminated in silicon-rich acid waters
AN increased level of aluminium in acidified natural waters is a primary cause of fish death from damage to gill epithelia and loss of osmoregulatory capacity1–4. Aluminium toxicity depends on the
...
...