Non-invasive prenatal determination of fetal sex: translating research into clinical practice.

  title={Non-invasive prenatal determination of fetal sex: translating research into clinical practice.},
  author={Melissa Hill and Kirstin M Finning and Philippe Martin and Jonathan Hogg and Cathy A. Meaney and Gail Norbury and Geoff Daniels and Lyn S. Chitty},
  journal={Clinical genetics},
  volume={80 1},
The effectiveness and clinical utility of non-invasive prenatal diagnosis (NIPD) for fetal sex determination using cell-free fetal DNA (cffDNA) was assessed by undertaking a prospective national audit of UK testing. NIPD was performed using real-time polymerase chain reaction analysis of the DYS14 or SRY gene in cffDNA extracted from maternal plasma. All cases referred for fetal sex determination from 1 April 2006 to 31 March 2009 were ascertained from two laboratories offering the test. Fetal… CONTINUE READING
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