Non-invasive optical spectroscopy and imaging of human brain function

@article{Villringer1997NoninvasiveOS,
  title={Non-invasive optical spectroscopy and imaging of human brain function},
  author={Arno Villringer and Britton Chance},
  journal={Trends in Neurosciences},
  year={1997},
  volume={20},
  pages={435-442}
}
View on Elsevier
ctools.umich.edu
1,548 Citations
Highly Influential Citations
73
Background Citations
472
Methods Citations
305
Results Citations
10

Figures from this paper

1,548 Citations

Non-invasive NIR spectroscopy of human brain function during exercise.
Optical detection of brain function: simultaneous imaging of cerebral vascular response, tissue metabolism, and cellular activity in vivo
TLDR
A new multimodality imaging platform is reported that combines DW-LSI, DFR-OCT, and calcium fluorescence imaging for simultaneous detection of cortical hemodynamics, cerebral metabolism, and neuronal activities of the animal brain in vivo, as well as its integration with microprobes for imaging neurons in deep brain regions in vivo.
History of Diffuse Optical Spectroscopy of Human Tissue
Diffuse optical spectroscopy is a noninvasive method that uses low levels of near-infrared light to measure blood oxygenation in the brain. Over the last 35 years, the number of diffuse optical…
In-vivo Optical Measurement of Neural Activity in the Brain
TLDR
The principles, the instrumentations and in vivo applications of those optical signal measurements are described and two most popular activity-dependent fluorescent probes, calcium indicators and voltage-sensitive fluorescent proteins will be examined in this review.
Beyond the Visible—Imaging the Human Brain with Light
  • H. Obrig, A. Villringer
  • Biology
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2003
TLDR
NIRS imaging has two major advantages: it can address issues concerning neurovascular coupling in the human adult and can extend functional imaging approaches to the investigation of the diseased brain.
Time-resolved multi-channel optical system for assessment of brain oxygenation and perfusion by monitoring of diffuse reflectance and fluorescence
Time-resolved near-infrared spectroscopy is an optical technique which can be applied in tissue oxygenation assessment. In the last decade this method is extensively tested as a potential clinical…
Functional Infrared Imaging for Biomedical Applications
TLDR
Near-infrared spectroscopy and spectroscopic imaging of tissue has been used to image the brain in action and to study the response of skin to damage and disease.
Near-infrared spectroscopy: does it function in functional activation studies of the adult brain?
  • H. Obrig, R. Wenzel, A. Villringer
  • Biology
    International journal of psychophysiology : official journal of the International Organization of Psychophysiology
  • 2000
Development of integrated semiconductor optical sensors for functional brain imaging
TLDR
This dissertation concentrates on key engineering challenges of implementing a single-chip semiconductor sensor using arrays of sources and detectors operating at near-infrared (NIR) wavelengths that reduces or eliminates the need for traumatic surgery and enables long-term brain-mapping studies in freely-behaving animals.
Simultaneous assessment of human brain functional hemodynamics by magnetic resonance and near-infrared imaging
Near-infrared spectroscopy is a relatively new imaging method, which can provide important information on concentrations of oxy-and deoxy-hemoglobin in cortical areas of the brain. We discuss the…
...
...

References

SHOWING 1-10 OF 82 REFERENCES
Simultaneous Recording of Cerebral Blood Oxygenation Changes during Human Brain Activation by Magnetic Resonance Imaging and Near-Infrared Spectroscopy
  • A. Kleinschmidt, H. Obrig, J. Frahm
  • Biology, Medicine
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 1996
TLDR
Results underline the hitherto assumed signal physiology for functional brain mapping by oxygenation-sensitive MRI and allow assessment of both constraints and practicability of functional studies by NIRS.
Coupling of brain activity and cerebral blood flow: basis of functional neuroimaging.
TLDR
The function, the mediators, and the hemodynamic mechanisms of coupling are considered and the potential interference by diet, and neurological disease is pointed out.
Dynamic multichannel near-infrared optical imaging of human brain activity.
TLDR
Functional brain mapping with an optical imaging technique by using tissue-transparent near-infrared light shows that there were regional variations of the oxygen delivery-oxygen utilization relationship during activation of brain activity.
Optical imaging of epileptiform and functional activity in human cerebral cortex
TLDR
The adaptation of high-resolution optical imaging for use on human cortex provides a new technique for investigation of the organization of the sensory and motor cortices, language, and other cognitive processes.
Noninvasive cerebral optical spectroscopy for monitoring cerebral oxygen delivery and hemodynamics
TLDR
The approach used overcomes previously identified difficulties with cerebral oximetry, and demonstrates excellent in vitro correlation, and can be performed clinically without difficulty.
Functional architecture of cortex revealed by optical imaging of intrinsic signals
TLDR
It is shown that some intrinsic changes in the optical properties of the tissue are dependent on electrical or metabolic activity and can be used to study the functional architecture of cortex.
Real-time optical imaging of naturally evoked electrical activity in intact frog brain
TLDR
It is demonstrated that optical measurements can be used for real-time imaging of spatio-temporal patterns of neuronal responses and for identification of functional units evoked by natural visual stimuli.
Near infrared spectroscopy (NIRS): A new tool to study hemodynamic changes during activation of brain function in human adults
Assessment of local brain activation. A simultaneous PET and near-infrared spectroscopy study.
TLDR
In five healthy human subjects, near-infrared spectroscopy (NIRS) and positron emission tomography (PET) examinations were performed simultaneously and a statistically significant correlation between changes in CBF and changes in [total-Hb] was found, confirming the validity of NIRS measurements in human adults.
Spatial and temporal analysis of human motor activity using noninvasive NIR topography.
TLDR
It was found that the regional change in cerebral blood volume in the primary motor area overlaps the global change around the motor cortex.
...
...