Non-invasive imaging of GFAP expression after neuronal damage in mice

@article{Zhu2004NoninvasiveIO,
  title={Non-invasive imaging of GFAP expression after neuronal damage in mice},
  author={Lingyun Zhu and Sylvie Ramboz and Duane D. Hewitt and Landin Boring and Anthony F. Purchio},
  journal={Neuroscience Letters},
  year={2004},
  volume={367},
  pages={210-212}
}
Up-regulation of glial fibrillary acidic protein (GFAP) expression is often used as a surrogate marker of neuronal damage. We have created a transgenic mouse line that carries the luciferase gene under the transcriptional control of the mouse GFAP promoter. Biophotonic imaging was used to non-invasively detect the increase in GFAP expression after kainic acid induced neuronal cell death. We demonstrate that after kainic acid treatment, strong biophotonic signals were detected from the brain… CONTINUE READING
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