Non-invasive fetal RHD genotyping in the first trimester of pregnancy

  title={Non-invasive fetal RHD genotyping in the first trimester of pregnancy},
  author={L. Cardo and B. Garc{\'i}a and F. {\'A}lvarez},
  booktitle={Clinical chemistry and laboratory medicine},
  • L. Cardo, B. García, F. Álvarez
  • Published in
    Clinical chemistry and…
  • Medicine
  • Abstract Background: Hemolytic disease of the fetus and newborn (HDN) is caused primarily by feto-maternal RhD incompatibility. Although all RhD negative pregnant women undergo routine antenatal RhD prophylaxis at 28 weeks of gestation, and following delivery if the newborn is RhD positive, HDN has not been eradicated. Here, we investigated fetal Rhesus D (RHD) genotype in maternal plasma during the first trimester of pregnancy in our area. Methods: Plasma samples were obtained from 111 RhD… CONTINUE READING
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