Non-invasive biomarkers derived from the extracellular matrix associate with response to immune checkpoint blockade (anti-CTLA-4) in metastatic melanoma patients

@inproceedings{Jensen2018NoninvasiveBD,
  title={Non-invasive biomarkers derived from the extracellular matrix associate with response to immune checkpoint blockade (anti-CTLA-4) in metastatic melanoma patients},
  author={Christina Jensen and Daniel H Madsen and Morten S{\o}es Hansen and Henrik Schmidt and Inge Marie Svane and Morten Asser Karsdal and Nicholas Willumsen},
  booktitle={Journal for immunotherapy of cancer},
  year={2018}
}
BackgroundExcessive extracellular matrix (ECM) remodeling and a reactive stroma can affect T-cell infiltration and T-cell activity in the tumor and hereby influence response to immune checkpoint inhibitors (ICI). In the pursuit of finding biomarkers that predict treatment response, we evaluated the association between serum biomarkers of collagen and vimentin turnover and outcomes in metastatic melanoma patients treated with the anti-CTLA-4 antibody ipilimumab (IPI).MethodsType III collagen… CONTINUE READING
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