Non-invasive and real-time passive acoustic mapping of ultrasound-mediated drug delivery.

@article{Choi2014NoninvasiveAR,
  title={Non-invasive and real-time passive acoustic mapping of ultrasound-mediated drug delivery.},
  author={James J. Choi and Robert C. Carlisle and Christian M Coviello and Len W Seymour and Constantin-C Coussios},
  journal={Physics in medicine and biology},
  year={2014},
  volume={59 17},
  pages={
          4861-77
        }
}
New classes of biologically active materials, such as viruses, siRNA, antibodies and a wide range of engineered nanoparticles have emerged as potent agents for diagnosing and treating diseases, yet many of these agents fail because there is no effective route of delivery to their intended targets. Focused ultrasound and its ability to drive microbubble-seeded cavitation have been shown to facilitate drug delivery. However, cavitation is difficult to control temporally and spatially, making… CONTINUE READING
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