Non-invasive and quantitative near-infrared haemoglobin spectrometry in the piglet brain during hypoxic stress, using a frequency-domain multidistance instrument.

@article{Hueber2001NoninvasiveAQ,
  title={Non-invasive and quantitative near-infrared haemoglobin spectrometry in the piglet brain during hypoxic stress, using a frequency-domain multidistance instrument.},
  author={Dennis M Hueber and Maria Angela Franceschini and H. Y. Ma and Qiong Zhang and Juan R. Ballesteros and Sergio Fantini and Donald H. Wallace and Vasilis Ntziachristos and Britton Chance},
  journal={Physics in medicine and biology},
  year={2001},
  volume={46 1},
  pages={41-62}
}
The frequency-domain multiple-distance (FDMD) method is capable of measuring the absolute absorption and reduced scattering coefficients of optically turbid media. Absolute measurement of absorption at two near-infrared (NIR) wavelengths makes possible the quantitation of tissue haemoglobin concentration and tissue haemoglobin oxygen-saturation (StO2). However, errors are introduced by the uncertainties of background absorption and the dissimilarities between real tissues and the simplified… CONTINUE READING